Dent Res J Isfahan. Dental history revealed that the patient had undergone scaling 18 months ago, after which there was only little reduction in the size of enlargement. Gingiva was reddish pink, soft and bled on probing.
Dose-dependent gingival overgrowth induced by cyclosporin in rats. Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporine A therapy. A single case of gingival overgrowth has been associated with the use of erythromycin in a young boy Valsecchi and Cainelli, The subjects taking nifedipine appeared to be at more risk for developing enlargement than those taking amlodipine.
Report of two cases and complications in management. Ahmed Dental College and Hospital, Kolkata with complaints of gingival enlargement with foul odor, bleeding and fetid discharge from gums since 1 year.
It gradually becomes a source of pain and the condition often leads to disfiguration. Proliferative and inductive effects of Cyclosporine a on gingival fibroblast of child and adult. Based on the clinical evaluation of the soft-tissue response to scaling and the persistence of fibrotic component on the lingual aspect of mandibular incisors, gingivectomy was performed to remove the localized growth from the lingual aspect of mandibular incisors.
Triveni et al19 reported a similar case of drug-induced gingival enlargement. This article throws light on respective drugs and their association with gingival overgrowth and approaches to treatment based on current knowledge and investigative observations. Interdisciplinary management of a patient with a drug-induced gingival hyperplasia.
The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients.
Gingiva was inflammed and soft to firm in consistency [ Figure 1a ]. Intraoral examination revealed poor oral hygiene, generalized nodular enlargement of gingiva mainly on the facial aspect of teeth. Vipin Bharti, 70, Sibia Colony, Opp.
Two weeks later, the growth was excised from the lingual aspect of mandibular incisors and sent for histopathologic examination Figure 3after which the area was sutured with silk. However a total or partial internal gingivectomy approach has been suggested as an alternative. It also has been proposed that susceptibility or resistance to pharmacologically induced gingival enlargement may be governed by the existence of differential proportions of fibroblast subsets in each individual which exhibit a fibrogenic response to this medication.
J Contemp Dent Pract. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia. The authors were unable to suggest any possible mechanism for the phenomenon. Calcium channel blockers and gingival overgrowth.
Oxford University Press; When this treatment approach is take as suggested by another case report, it may take from 1 to 8 weeks for resolution of gingival lesions. Diphenylhydantoin dilantin gingival hyperplasia: Drug substitution and surgical intervention was performed in first two cases.
variables, drug-influenced alterations in gingival connective tissue homeostasis, histopathology, ultrastructural factors, inflammatory changes and drug-induced actions on growth factors8.
Gingival overgrowth influenced by Amlodipine usually begins at the interdental papilla, which occurs within 6 months of taking medications at a dose of 10mg/day. This case reports a rare case of Amlodipine induced gingival enlargement.
The patient was successfully managed by drug substitution and nonsurgical periodontal terapy. Nonsurgical Management of Amlodipine Induced Gingival Enlargement – A Case Report. Nitesh kumar Sharma 1, Schneider LC. Periodontal management of gingival overgrowth.
odontal management and maintenance. Case Report: Gingival overgrowth influenced by Amlodipine usually begins at the interdental papilla, which occurs within 6 months of taking medications at a dose of 10mg/day.
Few cases have reported at a dose of 5 mg of Amlodipine when. The prevalence of amlodipine-induced gingival overgrowth was reported to be % (Jogersen, ).
The underlying mechanism of gingival enlargement still remains to be fully understood. However, two main inflammatory and non-inflammatory pathways have already been suggested.
Amlodipine-Induced Gingival Overgrowth: A Case Report Yogesh Upadhyay This case report describes the management of gingival overgrowth in a hypertensive patient taking amlodipine. Combination of surgical gingivectomy and (Hallmon and Rossman, ).
The treatment may consist of. The prevalence with amlodipine, %, is much lower.
3 Seymour et al 4 were the first to report on amlodipine-induced gingival overgrowth, and there have been only few reported associations of gingival overgrowth with this drug.Management of amlodipine influenced gingival overgrowth